THE ESTROGENIC ACTIVITIES OF KEBAR GRASS EXTRACT (Biophytum petersianum) ON WHITE FEMALE MICE (Mus musculus)

Sara Azzahra, Mulyati Effendi, Prasetyorini Prasetyorini

Abstract


Menopause occurs caused by the decline of estrogen hormone due to the depletion of the ovarian egg. As estrogen levels decrease, the risk of osteoporosis, bone fractures, heart disease and even cancer increase. The kebar grass (Biophytum petersianum). which has long been used as a traditional fertility medicine by Papuans, is suspected to have an estrogenic activity. The purpose of this study was to determine the estrogenic activity of kebar grass extract on female mice (Mus musculus). Five experimental female mice groups were used in this study. Each group consisted of 5 mice. The negative control group was administered with aquadest; the positive control was administered with esthero conjugated estrogen 0.625 mg; the first group (P1) was administered with 3% kebar grass extract; the (P2) group was administered with 5% kebar grass extract and the (P3) was administered with 10% kebar grass extract. The experiment was carried out for 7 days. The results of the study showed that the kebar grass extract has an estrogenic effects on female mice include to shorten the estrous cycle, prolong the estrous phase, improving the vascularity of ovary and uterus, and increase the weight of ovary and uterus. The highest estrogenic activity was reached when the mice was administered with 10% kebar grass extract.

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References


Albrecht ED, Pepe GJ., 2008. Steroid Endocrinology of Pregnancy. GLOWM.

Badzaid A. 2003. Endokrinologi ginekologi, edisi ke2. Jakarta : KSERI

Frasor, J; Barnett, D.H; Danes, J.M; Hess, R., Parlow, A.F; and Kastzenellenbogen, B.S. 2003. Response-Spesific and Ligand Dose Dependent Modulation of Estrogen Reseptor (ER) Alpha Activity by ER Beta in The Uterus. Endocrinology. 144: 3159-3166.

Hafez, E.S.E; dan Jainudeen, M.R. 2000. Hormones, Growth Factors and Reproduction. Di dalam: Reproduction in farm animals. Ed-3. Lippincott Williams & Wilkins. Philadelphia. Hlm. 31-54.

Lee, G.S; Hoe-Jin, K; Yong-Woo, J; Kyung-Chul, C; and Eui-Bae, J. 2005. Estrogen Receptor α Pathway is Involved in the Regulation of Calbindin-D9K in the Uterus of Immature Rats, Toxicology Sciences, 84(2): 270-277.

Lefaan, P N. 2014. Pengaruh Infusa Rumput Kebar (Biophytum petersianum) terhadap Spermatogenesis Mencit (Mus musculus). Jurnal Sain Veteriner. 32:1

Llewellyn, D; dan Jones. 2009. Setiap Wanita. PT. Delapratasa Publishing. Hlm 420; 421.

Martin, E W; Coock, E. F. 1961. Remington’s Praktice Of Pharmacy. (12rd Ed) Easton Pennsylvalnia: Mack Publishing Company.

Manalu, W. dan M. Y. Sumaryadi. 1995. Hubungan Antara Konsentrasi Progeteron dan Estradiol Dalam Serum Induk Selama Kebuntingan Dengan Massa Fetus Pada Akhir Kebuntingan. Prosiding Seminar Nasional Sains dan Teknologi Peternakan BPT. Ciawi. Bogor. Pp:57-62.

Nugroho, T., dan Scorviani, V. 2010. Kamus Pintar Kesehatan. Yogyakarta: Nuha Medika. Hlm. 173.

Proverawati, A. 2010. Menopause dan Sindrome Premenopause. Yogyakarta: Nuha Medika. Hlm. 1-2.

Ruggiero, J., and Likis, F.E., 2002, Estrogen: Physiology, Pharmacology, and Formulations for Replacement Therapy, J. Midwifery Womens Health, 47(3): 130-138.

Rugh, R. 1968. The Mouse Reproduction and Development. Burgess Publishing Company. Menneapolis. USA

Sadsoeitoeboen, Petrus D. 2005. Manfaat Ekstrak Rumput Kebar (Biophytum petersianum) Terhadap Penampilan Reproduksi Mencit Putih Betina. Thesis. Program Studi Biologi Reproduksi Sekolah Pascasarjana: Institut Pertanian Bogor.

Sembiring B dan I Darwati. 2010. Pemanfaatan Rumput Kebar (Biophytum petersianum). Warta Puslitbang. 19 (2): 16-18.

Sembiring, B; dan Darwati, I. 2013. Rumput Kebar (Biophytum petersianum) Sebagai Peningkat Fertilitas. http://perkebunan.litbang.pertanian.go.id. Diakses Pada Tanggal 04 Januari 2017 pada pukul 10.19 WIB.

Smith, J.B. dan S. Mangkoewidjojo. 1988. Pemeliharaan, Pembiakan Dan Penggunaan Hewan Percobaan Di Daerah Tropis. UI Press. Jakarta. hlm. 37-57.

Sembiring, B; dan Darwati, I. 2014. Identifikasi Komponen Kimia Aksesi Rumput Kebar (Biophytum petersianum) Asal Papua dan Jawa. Bul. Littro, Mei; 25 (1): 37-38.

Schramm W, Einer-Jensen N, Brown MB, McCracken JA. 1984 . Effect of four primary prostaglandins and relaxin on blood flow in the ovine

endometrium and myometrium. Biol Reprod 30: 523-531.

Toelihere, M.R. 1995. Fisiologi Reproduksi pada Ternak. Penerbit Angkasa: Bandung

Wajo, MJ. 2005. Pengaruh Pemberian Ekstrak Rumput Kebar (Biophytum petersianum) melalui Air Minum Terhadap Fertilitas Ayam Buras: Universitas Papua.


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